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Since , we meet or beat the prices of authorized dealers. We guarantee it! All this plus the best service, quality and state-of-the-art shipping in the world of fine art! Most items ship free! The son of an art professor at the Art Academy of China, Mo was educated in China and is one of the few artists ever honored with shows at both the National Theater and the National Gallery in Beijing.
He came to the U. He was one of a number of Chinese artists who attracted the attention of Dave Usher, the late founder of The Greenwich Workshop, who was a pioneer in gaining exposure for their work in the United States. In both countries, fellow artists never fail to be impressed with his remarkable ability to balance his subject with the very air and light around it. To his pleasure, he finds many of the same moods in America that he grew up with in China.
Her work has appeared on numerous book covers and in exhibitions and permanent collections nationwide. Still, his tender and nostalgic portrayals of children have earned him a wide and ardent following among collectors. Born in Oklahoma and raised throughout the West, Jim developed an early appreciation for the art of Norman Rockwell and at a young age knew he wanted to be a painter himself.
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More recently, there has been a strong focus towards this approach applied to non-invasively acquired samples, such as saliva and exhaled breath. The analysis of these biological samples, in conjunction with other sample types and traditional diagnostic tests, has resulted in faster and more reliable characterization of a range of health disorders and diseases. As the sampling process involved in collecting exhaled breath and saliva is non-intrusive as well as comparatively low-cost and uses a series of widely accepted methods, it provides researchers with easy access to the metabolites secreted by the human body.
Owing to its accuracy and rapid nature, metabolomic analysis of saliva and breath known as salivaomics and breathomics, respectively is a rapidly growing field and has shown potential to be effective in detecting and diagnosing the early stages of numerous diseases and infections in preclinical studies. This review discusses the various collection and analyses methods currently applied in two of the least used non-invasive sample types in metabolomics, specifically their application in salivaomics and breathomics research.
Some of the salient research completed in this field to date is also assessed and discussed in order to provide a basis to advocate their use and possible future scientific directions. If done correctly, metabolomics can provide an unbiased analysis of all such small-molecule metabolites collectively known as the metabolome within a given biological system, under a given set of conditions, through the analysis of a variety of different and complementary samples [ 3 ]. As such, metabolomics has the potential to improve disease diagnosis as well as the characterization of underlying pathological mechanisms, and more broadly, monitoring and understanding phenotypic variation; a clear differentiator from genomic and transcriptomic based approaches [ 2 ].
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Smooth muscle cell phenotypic switching in stroke. Disruption of cerebral blood flow after stroke induces cerebral tissue injury through multiple mechanisms that are not yet fully understood. Smooth muscle cells SMCs in blood vessel walls play a key role in cerebral blood flow control. Cerebral ischemia triggers these cells to switch to a phenotype that will be either detrimental or beneficial to brain repair. Moreover, SMC can be primarily affected genetically or by toxic metabolic molecules.
After stroke, this pathological phenotype has an impact on the incidence, pattern, severity, and outcome of the cerebral ischemic disease. Although little research has been conducted on the pathological role and molecular mechanisms of SMC in cerebrovascular ischemic diseases, some therapeutic targets have already been identified and could be considered for further pharmacological development. We examine these different aspects in this review. Phenotypic switching of populations of cells in a stochastic environment.
In biology phenotypic switching is a common bet-hedging strategy in the face of uncertain environmental conditions. Existing mathematical models often focus on periodically changing environments to determine the optimal phenotypic response. We focus on the case in which the environment switches randomly between discrete states.